The Klondike is a region of the territory of Yukon, in northwestern Canada. It lies around the Klondike River, a small river that enters the Yukon River from the east at Dawson City. The area is merely an informal geographic region, and has no function to the territory as any kind of administrative region. It is located in the traditional territory of the Tr’ondëk Hwëch’i…The Klondike is a region of the territory of Yukon, in northwestern Canada. It lies around the Klondike River, a small river that enters the Yukon River from the east at Dawson City. The area is merely an informal geographic region, and has no function to the territory as any kind of administrative region. It is located in the traditional territory of the Tr’ondëk Hwëch’in First Nation.