As Kelly Monaco wraps her 21-year General Hospital run, it's hard to forget the impact the actress and her character, Sam McCall, have had on the soap.

It would seem that Sam McCall’s fate is sealed. Kelly Monaco has even finished working at General Hospital. Rumors have started swirling that Cyrus Renault kills her character by injecting digitalis into her IV after she undergoes surgery to donate part of her liver to boyfriend Dante Falconeri’s comatose former wife,

Sam McCall has been a staple on General Hospital ever since her character arrived in 2003. Kelly Monaco joined the show after the cancellation of Port Charles, the GH spinoff. While she played Livvie Locke on Port Charles, Sam McCall was a new character created for General Hospital.

Way to say everything that need be said without uttering a single word, Kelly Monaco. In the October 24 episode of General Hospital, as Sam was wheeled on a gurney into an elevator on her way to surgery,

General Hospital's Thursday show had fans emotional as they watched what appeared to be Kelly Monaco’s heartfelt last moments with some of her co-stars

As Kelly Monaco’s final scenes as Sam McCall on General Hospital begin airing, viewers are tuned in to catch the final glimpses of one of their favorites. Kelly has played Sam since 2003, when the character debuted in Port Charles.

After two decades on General Hospital, it was announced that Kelly Monaco would not be returning as Sam McCall — and she's not happy about it.