The findings offer a promising drug target to prevent progression to colon cancer by targeting abnormal cells early on.

Researchers in the lab of Michael Sigal at the Max Delbrück Center and Charité – Universitätsmedizin Berlin have elucidated ...

New research highlights a pivotal role for the p53 gene in ulcerative colitis progression, offering a potential therapeutic ...

Results provide a mechanistic explanation of why early loss of p53 signaling is frequently observed in UC-associated ...

In a recent perspective published in the journal Cell Death and Differentiation, researchers in France, Germany, and Sweden ...

Researchers in Michael Sigal’s lab at the Max Delbruck Center and Charite – Universitatsmedizin Berlin have discovered the ...

The findings were recently published in Communications Chemistry. p53 is central to the body's defense against cancer, tasked ...

p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

This is a high magnification view of cells in a live Drosophila embryo engineered with a reporter to visualize p53 activity. Activity here was triggered by radiation. This image relates to an ...

p53 lies at the hub of a vast signalling network. Polymorphisms in upstream activators, repressors or downstream effectors of p53 might individually modulate cancer risk or interact with ...

It causes mutations in the p53 tumor-suppressor gene as well as ras mutations, which are involved in the majority of human cancers. Aflatoxin has been shown to contaminate tobacco products.

Presentation Details: Title: CLSP-1025, a novel bispecific T cell engager targeting a p53 R175H mutant peptide presented by HLA-A*02:01 Presentation Type: Poster Abstract Number: 1061 Date and ...