In 2022, Van Nistelrooy, 48, got his first crack at coaching a senior team leading PSV following Roger Schmidt's departure. While he signed a three-year contract and began winning the 2022 Johan Cryuff Shield and 2022-23 KNVB Cup, Van Nistelrooy resigned with one match left in the season due to lack of support from management.

Manchester United’s interim manager, Ruud van Nistelrooy, believes the team can become “unstoppable,” though he cautions it will require time and relentless dedication to reach their full

Ruud van Nistelrooy will take charge of Man United for the first time when they face Leicester City in the Carabao Cup fourth round tonight.