The findings offer a promising drug target to prevent progression to colon cancer by targeting abnormal cells early on.

New research highlights a pivotal role for the p53 gene in ulcerative colitis progression, offering a potential therapeutic ...

Researchers in the lab of Michael Sigal at the Max Delbrück Center and Charité – Universitätsmedizin Berlin have elucidated ...

Results provide a mechanistic explanation of why early loss of p53 signaling is frequently observed in UC-associated ...

In a recent perspective published in the journal Cell Death and Differentiation, researchers in France, Germany, and Sweden ...

The findings were recently published in Communications Chemistry. p53 is central to the body's defense against cancer, tasked ...

Researchers in Michael Sigal’s lab at the Max Delbruck Center and Charite – Universitatsmedizin Berlin have discovered the ...

It seems, the team found, that some species may be more at risk of developing cancer than others. Among those with unusually ...

p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

p53 lies at the hub of a vast signalling network. Polymorphisms in upstream activators, repressors or downstream effectors of p53 might individually modulate cancer risk or interact with ...

It causes mutations in the p53 tumor-suppressor gene as well as ras mutations, which are involved in the majority of human cancers. Aflatoxin has been shown to contaminate tobacco products.

Presentation Details: Title: CLSP-1025, a novel bispecific T cell engager targeting a p53 R175H mutant peptide presented by HLA-A*02:01 Presentation Type: Poster Abstract Number: 1061 Date and ...